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. 2020 Jun 17;8:287. doi: 10.3389/fpubh.2020.00287

Table 3.

Symptoms for patients with primary DENV infections.

Dengue 1 Dengue 2 Dengue 3 Dengue 4
OR (95% CI) OR (95% CI) OR (95% CI) OR (95% CI)
N (%) N (%) N (%) N (%)
Arthralgia 0.0 4.0 (0.45–35.35) 2.34E−009 2.33 (0.22–24.4)
0 6 (14.2%) 0 1 (20%)
Myalgia 1.11 (0.25–4.84) 0.76 (0.28–2.05) 1.11 (0.31–3.89) 1.71 (0.26–10.93)
4 (50%) 19 (45.2%) 6 (50%) 3 (60%)
Headache 0.45 (0.06–2.91) 1.02 (0.37–2.8) 0.69 (0.15–3.09) 6.78 (0.71–64.42)
2 (25%) 17 (40.4%) 4 (33.3%) 4 (80%)
Rash 0.74 (0.08–6.82) 0.59 (0.15–2.28) 1.10 (0.2–5.99) 4.25 (0.61–29.520
1 (12.5%) 5 (12%) 2 (16.6%) 2 (40%)
Hemorrhagic manifestations 1.63 (0.31–10.75) 1.23 (0.33–4.61) 0.90 (0.17–4.76) 6.78E−009
2 (25%) 8 (19%) 2 (16.6%) 0
Fever ≥38°C 0.08 (0.010.75) 1.50 (0.54–4.15) 0.92 (0.24–3.390 618E+006
1 (12.5%) 23 (54.7%) 6 (50%) 5 (100%)
Nausea/vomiting 0.62 (0.13–2.89) 1.32 (0.44–3.92) 0.75 (0.19–2.86) 4.3 (0.23–78.63)
5 (62.5%) 31 (73.8) 8 (66.6%) 4 (80%)
Burning micturition 0.79 (0.08–7.25) 0.54 (0.13–2.09 2.28 (0.49–10.53) 1.47 (0.14–14.72)
1 (12.5%) 5 (12%) 3 (25%) 1 (20%)
Neurologic symptoms 2.37E−009 3.1 (0.61–15.88) 1.02 (0.19–5.47) 6.92E−009
0 9 (21.4%) 2 (16.6%) 0
Dengue fever diagnosis 1.62 (0.27 to 9.49) 0.96 (0.33–2.8) 0.87 (0.22–3.38) 0.73 (0.08–6.58)
6 (75%) 27 (62.4%) 7 (58.3%) 3 (60%)
Antibiotics prescribed 0.40 (0.07–2.15) 1.42 (0.50–4.03) 1.13 (0.3–4.2) 0.88 (0.13–5.670
2 (25%) 18 (42.8%) 5 (41.6%) 2 (40%)
Eye pain 0.0 204E+006 6.88E−009 0.0
0 3 (7%) 0 0
Fever ≥38.5°C 1.83E−009 0.91 (0.26–2.19) 2.78 (0.7–9.1) 1.55 (0.53–22.76)
0 12 (26.2%) 6 (50%) 2 (40%)

Logistic analysis was performed in which a single serotype was compared against the other serotypes. These patients were NS1 and RT-PCR positive for only one serotype and negative for DENV neutralizing antibodies via PRNT. Bold font indicates statistical significance. OR, odds ratio; CI, confidence interval; N, number of patients.