FIGURE 3.

Therapeutic applications of biomimetic nanoparticles in cardiovascular disease. (A,B) HDL-mimicking nanoparticles reduce plaque burden and infiltration of macrophages (red) in the aortic roots of atherosclerotic mice. (C,D) Rapamycin-loaded leukocyte-based nanoparticles for the treatment of atherosclerosis (C) Oil red O staining for lipid deposition in the aortas of atherosclerotic mice treated with or without nanoparticles (D) Image quantification of the plaque area with the vessels. Images in (A,B) are reproduced with permission from Tang et al. (2015). Images in (C,D) are reproduced with permission from Boada et al. (2020).