FIGURE 5.

Role of biomimetic nanoparticles in treatment of autoimmune diseases. (A,B) Specialized leukocyte-mimicking nanoparticles (SLK) with overexpression of α4β7 integrins for the treatment of inflammatory bowel disease. (A) Immunofluorescent imaging for CD45 + immune cells in the colon following treatment with and without nanoparticles resulted in the decreased immune filtration in the SLK group with overall improvement in the histology of the colon (B). (C,D) Red blood cell coated nanoparticles (RBC-ANS) for the clearance of pathological antibodies (C) Representative schematic demonstrating how RBC-ANS work to neutralize antibodies that would otherwise induce hemolysis (D) Significant improvements in RBC count, hemoglobin and hematocount were observed in mice treated with RBC-ANS compared to bare nanoparticles alone. Images in (A,B) are reproduced with permission from Corbo et al. (2017a). Images in (C,D) are reproduced with permission from Copp et al. (2014).