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. 2020 Jun 17;11:1256. doi: 10.3389/fimmu.2020.01256

Figure 1.

Figure 1

The DNA sensor cGAS mediates therapeutic responses to DNPs that suppress EAE. (A) IDO activity in spleens from WT and cGAS-KO (KO) mice treated with DNPs. (B) EAE was induced in B6 (WT) and cGAS-KO mice (see section Materials and Methods), and EAE progression was monitored and scored. Experimental groups (n = 10) were treated with DNPs (every other day from day 11–21) and control WT mice were treated with vehicle (glucose 5%). Data were analyzed by t-test for (A) and two-way ANOVA for (B). Experiments were repeated once. NS, not significant; ***p < 0.001, #p < 0.0001.