Table 4.
Dominant and recessive genetic models of MTHFR and PAI-1 polymorphisms
| SNP | Dominant model, n (%) | Recessive model, n (%) | |||
|---|---|---|---|---|---|
| UI patients | Controls | UI patients | Controls | ||
| MTHFR C677T | CC | 20 (19.1) | 49 (40.8) | 83 (79.0) | 104 (86.7) |
| CT | 85 (80.9) | 71 (59.2) | |||
| TT | 22 (21.0) | 16 (13.3) | |||
| OR (95%CI) | 2.93 (1.59–5.39) | 1.72 (0.85–3.49) | |||
| p value of χ2 | 0.0004* | 0.128 | |||
| PAI-1 4G/5G | 5G/5G | 18 (17.1) | 22 (18.3) | 81 (77.1) | 84 (70.0) |
| 4G/5G | 87 (82.9) | 98 (81.7) | |||
| 4G/4G | 24 (22.9) | 36 (30.0) | |||
| OR (95%CI) | 1.08 (0.54–2.16) | 0.69 (0.38–1.26) | |||
| p value of χ2 | 0.816 | 0.227 | |||
SNP, single nucleotide polymorphism; UI, unexplained infertility; MTHFR, methylenetetrahydrofolate reductase; PAI-1, plasminogen activator inhibitor 1; OR, odds ratio; CI, confidence interval
*Significant p value