Table 5.
Association of thrombophilia SNPs and UI, results of the logistic regressions
| B | OR | 95% CI | p value | |
|---|---|---|---|---|
| A model with all SNPs and genotypes | ||||
| FVL (GA) | 0.583 | 1.792 | 0.457–7.026 | 0.403 |
| FII (GA) | 0.663 | 1.941 | 0.430–8.767 | 0.389 |
| MTHFR | 0.004* | |||
| MTHFR (CT) | 1.026 | 2.790 | 1.473–5.285 | 0.002* |
| MTHFR (TT) | 1.097 | 2.996 | 1.262–7.116 | 0.018* |
| MTHFR (CC)** | − 1.097 | 0.334 | 0.141–0.793 | 0.013* |
| PAI1 | 0.610 | |||
| PAI1 (4G/4G) | − 0.043 | 0.958 | 0.413–2.220 | 0.920 |
| PAI1 (4G/5G) | 0.251 | 1.286 | 0.614–2.692 | 0.505 |
| A model with dominant and recessive MTHFR and PAI-1 genotype models | ||||
| MTHFR dominant (CT + TT vs. CC) | − 1.021 | 0.360 | 0.191–0.681 | 0.002* |
| MTHFR recessive (TT vs. CC + CT) | − 0.149 | 0.862 | 0.410–1.812 | 0.695 |
| PAI-1 dominant (5G/4G + 4G/4G vs. 5G/5G) | − 0.230 | 0.795 | 0.381–1.656 | 0.540 |
| PAI-1 recessive (4G/4G vs. 5G/5G + 5G/4G) | − 0.324 | 0.723 | 0.379–1.380 | 0.325 |
UI, unexplained infertility; FVL, factor V Leiden (G1691A); PGM, prothrombin G20210A mutation; MTHFR, methylenetetrahydrofolate reductase; PAI-1, plasminogen activator inhibitor 1; B, unstandardized regression weight; OR, odds ratio; CI, confidence interval
*Significant p value, ** the same model, but with TT genotype set as a reference for comparison of other MTHFR genotypes