Table 2.
Biodistribution of radiometal labelled CAIX-imaging probes in mice bearing SK-RC-52 xenografts. Results are presented as %ID/g (the mean values and standard deviation for four mice). Data for [88Y]Y-DOTA-G250 antibody are taken from (Brouwers et al. 2004) and tumour-to-organ ratios are calculated using uptake values. Data for [111In]In-DTPA-G250(Fab’)2 and [111In]In-DOTA-HE3-ZCAIX:2 are taken from (Garousi et al. 2019)
| [88Y]Y-DOTA-G250 antibody | [111In]In-DTPA-G250(Fab’)2 | [111In]In-DOTA-HE3-ZCAIX:2 | |||
|---|---|---|---|---|---|
| 72 h | 168 h | 4 h | 24 h | 4 h | |
| Uptake, %ID/g | |||||
| Tumor | 44±15 | 55±11 | 6±1 | 5±1 | 15±3 |
| Blood | 12.5±1.3 | 8.2±1.9 | 2.9±0.5 | 0.07±0.02 | 0.24±0.03 |
| Lung | 2.3±0.2 | 0.7±0.3 | 0.49±0.09 | ||
| Liver | 7.0±0.7 | 3.7±0.4 | 10±2 | 8±2 | 0.5±0.1 |
| Kidney | 216±30 | 145±9 | 392±26 | ||
| Muscle | 1.4±0.2 | 0.7±0.2 | 0.8±0.1 | 0.4±0.1 | 0.14±0.02 |
| Bone | 1.0±0.2 | 0.4±0.2 | 2.1±0.4 | 1.4±0.2 | 0.32±0.08 |
| Tumour-to-organ ratio | |||||
| Blood | 3.6 | 6.7 | 2.1±0.2 | 67±12 | 63±11 |
| Lung | 2.7±0.4 | 7±1 | 30±3 | ||
| Liver | 6.3 | 14.9 | 0.7±0.3 | 0.6±0.2 | 33±2 |
| Kidney | 0.029±0.005 | 0.03±0.01 | 0.038±0.008 | ||
| Muscle | 31.7 | 78 | 7.9±0.7 | 11±1 | 102±20 |
| Bone | 44 | 137 | 3.0±0.5 | 4±1 | 47±8 |