TABLE 1.

Summary of single-cell studies on mDA development and diversity.

References	Species	Dev stage/Age	Selection	Nr cells sampled	Transcriptional analysis	Highlighted findings
Tiklová et al., 2019	Mice	E13.5; E15.5; E18.5 P1; P7; P90	Pitx3-EGFP	1106	RNA-seq	Two main group of mDAs based on the level of expression of Dat (Dat-high and Dat-low); further sub-classification into seven distinct mDA subtypes; description of trajectory-specific transcription factors during mDA development.
Hook et al., 2018	Mice	E15 P7	Th-EGFP	396	RNA-seq	Presence of postnatal (P7) neuroblast population in dorsal SNc.
La Manno et al., 2016	Human	w6; w7; w8; w9; w10; w11	–	1977	RNA-seq	Description of diversity of human radial glia cell types; identification of three prenatal and five postnatal mouse mDA subtypes; machine learning approach to assess quality of hESC-derived mDAs.
	Mice	E11.5; E12.5; E13.5; E14.5; E15.5; E18.5; P19-27	Wild type	1907
		P28; P56	Dat1-Cre/tdTomato	245
Kee et al., 2017	Mice	E10.5; E11.5; E12.5; E13.5	Lmx1a-EGFP	550 (+ and – fraction)	RNA-seq	Close transcritptional relationship between mDAs and STN lineages; identification of early markers that predict graft outcome (see also Kirkeby et al., 2017).
Poulin et al., 2014	Mice	P4	Dat1-Cre/tdTomato	159	qRT-PCR	Identification of six neuronal mDA subtypes in mouse.