Table 2.
AQP4 and MOG peptides used for CD4+ T-cell stimulation.
| Peptide | Sequence | aa | Mr | References |
|---|---|---|---|---|
| AQP4 peptides | ||||
| 11–30 | GKCGPLCTRENIMVAFKGVW | 20 | 2,209 | (31, 36) |
| 61–80 | GTEKPLPVDMVLISLCFGLS | 20 | 2,119 | (31, 36) |
| 63–76 | EKPLPVDMVLISLC | 14 | 1,556 | (31) |
| 91–110 | ISGGHINPAVTVAMVCTRKI | 20 | 2,067 | (36) |
| 139–153 | PSVVGGLGVTMVHGN | 15 | 1,423 | (31, 51) |
| 156–170 | AGHGLLVELIITFQL | 15 | 1,623 | (31) |
| 211–230 | SMNPARSFGPAVIMGNWENH | 20 | 2,215 | (31, 36) |
| 281–305 | EDNRSQVETDDLILKPGVVHVIDVD | 25 | 2,805 | (37) |
| MOG peptides | ||||
| 1–20 | GQFRVIGPRHPIRALVGDEV | 20 | 2,216 | (39, 52) |
| 35–55 | MEVGWYRPPFSRVVHLYRNGK | 21 | 2,591 | (39, 42, 52) |
| 64–80 | EYRGRTELLKDAIGEGK | 17 | 1,934 | (52) |
| 81–96 | VTLRIRNVRFSDEGGF | 16 | 1,865 | (52) |
| 99–107 | FFRDHSYQE | 9 | 1,227 | (53) |
| 119–130 | FYWVSPGVLVLL | 12 | 1,392 | (41, 43) |
| 181–195 | TLFVIVPVLGPLVAL | 15 | 1,550 | (41) |
| 186–200 | VPVLGPLVALIICYN | 15 | 1,583 | (41) |
| 205–214 | RLAGQFLEEL | 19 | 1,174 | (54) |
Eight AQP4 and nine MOG peptides corresponding to intra-, extracellular and transmembrane domains of human AQP4 and MOG were selected based on their encephalitogenicity in animals and/or their immunodominance in humans.
Aa, number of amino acids; AQP4, aquaporin-4; MOG, myelin oligodendrocyte glycoprotein; Mr, molecular weight.