Fig. 2.

Vancomycin exposure postweaning altered colonic motility. A: representative spatiotemporal maps showing colonic motility patterns in a control and a vancomycin-treated 6-wk-old mouse treated postweaning, with all anally propagating contractions indicated by arrows. Anally propagating patterns that do not propagate past halfway along the length of the colon (open arrows) and those that do [colonic migrating motor complexes (CMMCs) closed arrows] are identified. Short contractions that occur in the anal regions (closed arrowheads) are also denoted. B–F: quantification of the frequency of all anally propagating contractions (B), length of anally propagating contractions (C), frequency of anal short contractions (D), frequency of CMMCs (E), speed of CMMCs (F), and resting gut width (G) of control- (Con) and vancomycin (Vanco)-exposed mice (n = 15–20 mice). Data are represented as means ± SE. Treatment groups were compared statistically using unpaired t tests or Mann-Whitney U tests. *P < 0.05; **P < 0.01.