Fig. 5.

Chronic inhibition of IL-17 in reduced uterine perfusion pressure (RUPP) rats increased circulating VEGF and decreased soluble fms tyrosine kinase-1 (sFlt-1). A subset of pregnant rats undergoing the RUPP procedure also received a miniosmotic pump infusing 100 pg/day of a soluble IL-17 receptor (IL-17RC) into the intraperitoneal cavity from gestational days (GD) 14–19. Placental VEGF (A), circulating VEGF (B), and circulating s-Flt1 (C) measured via ELISA are shown. Normal pregnant (NP): n = 10–11 rats; RUPP: n = 10–12 rats; RUPP + IL-17RC: n = 10–12 rats. All data are expressed as means ± SD. Statistical analysis was performed using one-way ANOVA with multiple comparisons followed by Tukey’s post hoc correction. *P < 0.05 vs. NP; #P < 0.05 vs. RUPP.