Table 1.

Effects of chronic IL-17 inhibition on litter size and fetal and placental weight in pregnant rats

	NP	RUPP	RUPP IL-17RC
Total litter size	15 ± 2	14 ± 2	14 ± 1
Total live pups	14.5 ± 2	7.8 ± 3*	11 ± 3*#
Fetal weight, g	2.4 ± 0.04	2.1 ± 0.04*	2.3 ± 0.05#
Placental weight, g	0.55 ± 0.01	0.43 ± 0.04*	0.52 ± 0.03#

All data are expressed as means ± SD. A subset of pregnant rats undergoing the reduced uterine perfusion pressure (RUPP) procedure also received a miniosmotic pump infusing 100 pg/day of a soluble IL-17 receptor (IL-17RC) into the intraperitoneal cavity from gestational days (GD) 14–19. After rats were euthanized on GD19, the average litter size, live pups, fetal weight, and placental weight were calculated for all groups. Normal pregnant (NP): n = 8–12 rats; RUPP: n = 7–12 rats; RUPP + IL-17RC: n = 7–12 rats. Statistical analysis was performed using one-way ANOVA with multiple comparisons followed by Tukey’s post hoc correction.

^*P < 0.05 vs. NP,

^#P < 0.05 vs. RUPP.