Table 2.
Expression of genes that were partially normalized in CBK hearts following SR-9009 administration for 8 days at ZT9
| ENSEMBL ID | Gene Description | CBK Vehicle vs. CON Vehicle (Fold Change), | CBK SR-9009 vs. CBK Vehicle (Fold Change) |
|---|---|---|---|
| Up in CBK vehicle ≥ 2.0-fold | Down in CBK SR-9009 ≤ −2.0-fold | ||
| ENSMUSG00000101144 | Predicted gene 29054 | 5.6 | −3.7 |
| ENSMUSG00000098194 | Predicted gene 7286 | 4.4 | −2.4 |
| ENSMUSG00000024211 | Glutamate receptor, metabotropic 8 | 3.2 | −2.1 |
| ENSMUSG00000044322 | Desmocollin 1 | 3.1 | −2.2 |
| Down in CBK vehicle up to −2.0-Fold | Up in CBK SR-9009 ≥ 2.0-Fold | ||
| ENSMUSG00000041771 | Solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 | −2.9 | 2.1 |
| ENSMUSG00000008932 | Solute carrier family 1 (glutamate transporter), member 7 | −3.5 | 2.6 |
| ENSMUSG00000085965 | RIKEN cDNA 2310016D23 gene | −3.6 | 2.4 |
| ENSMUSG00000092051 | Predicted gene 17229 | −3.7 | 2.2 |
| ENSMUSG00000016179 | Calcium/calmodulin-dependent protein kinase I gamma | −3.8 | 2.0 |
| ENSMUSG00000073399 | Tripartite motif-containing 40 | −4.0 | 2.6 |
| ENSMUSG00000086935 | Predicted gene 15956 | −4.5 | 2.0 |
| ENSMUSG00000044405 | Adipogenin | −4.6 | 2.0 |
| ENSMUSG00000105867 | Predicted gene 42517 | −4.6 | 2.2 |
| ENSMUSG00000025481 | Urate (5-hydroxyiso-) hydrolase | −4.8 | 2.3 |
| ENSMUSG00000026358 | Regulator of G protein signaling 1 | −5.1 | 2.5 |
| ENSMUSG00000050071 | Brain expressed X-linked 1 | −5.7 | 2.2 |
| ENSMUSG00000030336 | CD27 antigen | −6.0 | 3.4 |
| ENSMUSG00000030483 | Cytochrome P450, family 2, subfamily b, polypeptide 10 | −6.1 | 2.5 |
| ENSMUSG00000043999 | G protein-coupled receptor 75 | −6.1 | 2.5 |
| ENSMUSG00000061718 | Protein phosphatase 1, regulatory inhibitor subunit 1B | −7.0 | 2.1 |
| ENSMUSG00000051811 | Cytochrome c oxidase subunit 6B2 | −7.7 | 2.1 |
| ENSMUSG00000086645 | Predicted gene 15743 | −9.0 | 2.5 |
| ENSMUSG00000103476 | Predicted gene, 34302 | −9.1 | 2.1 |
| ENSMUSG00000079620 | Mucin 4 | −11.4 | 2.1 |
| ENSMUSG00000050423 | Protein phosphatase 1, regulatory subunit 3G | −18.6 | 2.0 |
| ENSMUSG00000028307 | Aldolase B, fructose-bisphosphate | −89.1 | 2.3 |
CBK, cardiomyocyte-specific BMAL1-knockout; CON, control; ZT9, zeitgeber time 9. Included are genes whose expression changed ≥2-fold in CBK vs. CON hearts (from vehicle-treated mice) and the same gene changed in the opposite direction ≥2-fold in CBK hearts following SR-9009 administration. RNA-seq data were used for this analysis.