Fig. 4.

Electrocardiographic analysis of synapse-associated protein 97 (Sap97) mice indicates repolarization abnormalities and spontaneous arrhythmias in Sap97-knockout (KO) mice. A: schematic representing details for analysis of ECG waveforms. Note typical changes (asterisks) in ST of KO animals displaying profound delayed repolarization effects. Surface ECGs performed under anesthesia (2% isoflurane) revealed several arrhythmias in Sap97-KO animals. B: example of atrioventricular dissociation, p wave moves independently of the QRS complex. C: short runs of premature ventricular contractions were frequently observed. Neither of these phenotypes were observed in wild-type (WT) animals (N = 7 Sap97KO; N = 6 WT).