Fig. 5.

Cardiosphere-derived cell (CDC)-extracellular vesicle (EV) upregulation of arginase 1 (Arg1) is regulated by miRNA cargo. A: PCR analysis with candidate miRNA (miR-146a) revealed significantly lower miRNA expression in CDC-EVs isolated from CDCs with a Drosha knockdown (KD) when compared with scrambled (Scr) control (n = 3 biological replicates, means ± SE, *P < 0.05, Student’s unpaired t test). B: CDC-EVs with a Drosha knockdown are unable to upregulate arginase-1 expression to the same level as control CDC-EVs (n = 3 biological replicates, means ± SE, *P < 0.05, one-way ANOVA).