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Schematic diagram illustrating the effects of cardiosphere-derived cell (CDC)-extracellular vesicles (EVs) on inflammatory macrophages and their regulation of a novel urea-cycle-dependent mechanism promoting angiogenesis. Arg1, arginase 1; NOHA, Nω-hydroxy-nor-l-arginine; OAT, ornithine aminotransferase; NOS2, nitric oxide synthase 2; ODC, ornithine decarboxylase.
