Fig. 5.
Effects of clodronate treatment on mean arterial pressure (MAP; A) and proteinuria (B) in wild-type Dahl salt-sensitive (SSWT) rats and obese Dahl salt-sensitive leptin receptor mutant (SSLepRmutant) rats. Numbers in parentheses indicate the number of rats studied per group. Values are means ± SE. Temporal changes in renal and cardiovascular parameters were compared between and within strains using two-way ANOVA followed by a Holm-Sidak test. The significance of difference in mean values for a single time point was determined by one-way ANOVA followed by a Tukey’s multiple-comparisons test. P values of <0.05 were considered significantly different. *Significant difference from the corresponding value within the same strain at baseline; †significant difference from the corresponding value in SSWT rats within the same treatment; #significant difference from the corresponding value in vehicle-treated rats within the same strain.