Fig. 6.
A and B: representative images of renal histopathology: periodic acid-Schiff staining (A) and Masson’s trichrome staining (B). C and D: effects of clodronate treatment on glomerular injury (C) and renal fibrosis (percent blue staining; D) in wild-type Dahl salt-sensitive (SSWT) rats and obese Dahl salt-sensitive leptin receptor mutant (SSLepRmutant) rats. For glomerular injury, the numbers in parentheses indicate the number of glomeruli/rats studied per group; for renal fibrosis, the numbers in parentheses indicate either the number of images/rats studied per group. Values are means ± SE. The significance of difference in mean values for a single time point was determined by one-way ANOVA followed by a Tukey’s multiple-comparisons test. P values of <0.05 were considered significantly different. †Significant difference from the corresponding value in SSWT rats within the same treatment; #significant difference from the corresponding value in vehicle-treated rats within the same strain.