Fig. 3.

Acute effect of ANG II infusion in afferent arterioles under high renal perfusion pressure (RPP) followed by P2X₁ receptor (P2X₁R) or ANG II type 1 receptor (AT₁R) inhibition in normotensive rats. The afferent arteriolar response to ANG II (1 nmol/L) superfusion of the vessel at 100 mmHg was followed by a step increase in RPP to reach 140 mmHg. Superfusion of the P2X₁R inhibitor (P2X₁Ri) was then followed by the AT₁R inhibitor (AT₁Ri; n = 7). Data are expressed as means ± SD. *P < 0.05 vs. RPP at 100 mmHg; #P < 0.05 vs. RPP at 100 mmHg + ANG II; &P < 0.05 vs. RPP at 140 mmHg + ANG II.