Fig. 5.

Effects of P2X₇ receptor (P2X₇R) or ANG II type 1 receptor (AT₁R) inhibition alone and P2X₁ receptor (P2X₁R) plus P2X₇R blockade on the afferent arteriolar response to an increase in renal perfusion pressure (RPP) in hypertensive rats. A: afferent arteriolar responses to increases in RPP were followed by P2X₇R inhibitor (P2X₇Ri) and AT₁R inhibitor (AT₁Ri). B: afferent arteriolar responses to increases in RPP followed by AT₁Ri and P2X₇R inhibitor (P2X₇Ri) and the combination of P2X₁Ri plus P2X₇Ri. Data are expressed as means ± SD; n = 5 per group. *P < 0.05 vs. RPP at 100 mmHg; #P < 0.05 vs. RPP at 140 mmHg; &P < 0.05 vs. RPP at 140 mmHg + AT₁Ri; ^αP < 0.05 vs. RPP at 140 mmHg + P2X₇Ri.