Table 1.
Telemetry values
| Low K+ | Ctrl | K+ Basic | KCl | |
|---|---|---|---|---|
| Day 4 (22 h) | ||||
| SBP, mmHg | 138 (2.2) | 133 (2.2) | 136 (1.6) | 137 (2.6) |
| DBP, mmHg | 96 (1.5) | 98 (1.5) | 97 (1.2) | 99 (2.6) |
| MAP, mmHg | 116 (1.7) | 115 (1.8) | 116 (1.3) | 117 (2.4) |
| HR, beats/min | 479 (12)† | 557 (8) | 545 (8) | 504 (5)*‡ |
| Pulse pressure, mmHg | 41 (1.0)† | 35 (0.8) | 39 (0.6) | 38 (1.4) |
| Activity, arbitrary units | 1.7 (0.2) | 2.0 (0.4) | 2.0 (0.2) | 2.5 (0.3) |
| Day 10 (22 h) | ||||
| SBP, mmHg | 136 (2.7) | 135 (1.4) | 149 (2.6)† | 145 (2.9)† |
| DBP, mmHg | 97 (2.1) | 97 (1.3) | 107 (2.0)† | 106 (3.7)* |
| MAP, mmHg | 115 (2.4) | 116 (1.3) | 128 (2.3)† | 125 (3.1)* |
| HR, beats/min | 430 (8)† | 540 (13) | 518 (4) | 510 (15) |
| Pulse pressure, mmHg | 39 (0.7) | 38 (0.4) | 42 (0.9) | 39 (2.5) |
| Activity, arbitrary units | 2.0 (0.3) | 2.0 (0.1) | 2.6 (0.2) | 3.5 (0.3)† |
Values are means (SE) and represent an average of 264 measurements per day; n = mice per diet. On day 4, varying dietary K+ had no significant effect on 22-h systolic blood pressure (SBP), diastolic blood pressure (DBP), or mean arterial pressure (MAP). Mice fed the low-K+ diet and KCl diet did have a significant decrease in heart rate (HR) compared with control. At day 10, both high-K+ diets elevated blood pressure compared with control [SBP (10–14 mmHg), DBP (9–10 mmHg), and MAP (9–12 mmHg)]. Additionally, at 10 days, the low-K+ diet caused a significant decrease in HR compared with control. Two-way ANOVA followed by Dunnett’s post hoc test was used.
P ≤ 0.05 and
P ≤ 0.01, significant difference from the control diet.
Significant difference between the K+ basic and KCl diets.