Table 2.
Effect of 10 days of dietary K+ on whole blood parameters and urine pH
| Low K+ | Control | K+ Basic | KCl | |
|---|---|---|---|---|
| Change in weight at 10 days, g | −0.55 (0.53) | +0.94 (0.34) | −0.15 (0.43) | −0.71 (0.51) |
| Day 10 whole blood | ||||
| Na+, mmol/L | 147.4 (0.61)* | 144.2 (0.41) | 144.3 (0.66) | 146.2 (0.92) |
| K+, mmol/L | 2.88 (0.08)† | 4.06 (0.09) | 4.93 (0.21)† | 5.34 (0.21)† |
| Cl−, mmol/L | 112 (0.48) | 112.5 (0.34) | 113.1 (0.83) | 119.5 (1.27)†‡ |
| Ionized Ca2+, mmol/L | 1.24 (0.02) | 1.29 (0.02) | 1.21 (0.03) | 1.31 (0.03)‡ |
| Total CO2, mmol/L | 24.3 (0.62) | 23.5 (0.29) | 24.4 (0.74) | 20.8 (0.48)†‡ |
| Glucose, mg/dL | 208.6 (4.66) | 217.8 (9.10) | 181.2 (7.06)† | 187.5 (9.60)* |
| Blood urea nitrogen, mg/dL | 25.83 (2.28) | 22.33 (0.89) | 23.08 (1.23) | 25.36 (1.70) |
| Hct, %packed cell volume | 41.67 (1.20) | 41.25 (0.76) | 38.00 (0.58)* | 37.27 (0.97)* |
| Aldosterone, pg/mL | 83 (17)* | 385 (66) | 929 (242)* | 2889 (390)†‡ |
| Day 10 (spot urine) pH | 7.2 (0.13)* | 6.5 (0.19) | 7.2 (0.26)* | 6.0 (0.04)‡ |
Values are means (SE). For the change in weight, n = 16–18 mice per diet; for whole blood and urine pH, n = 12 mice per diet. One-way ANOVA with Sidak’s post hoc analysis was used.
*
P ≤ 0.05 and
†
P ≤ 0.01, significant difference from the control diet.
‡
Significant difference between K+ basic and KCl.