Table 4.

Twenty-four hour averages of telemetry parameters measured for 3 continuous days

Telemeter Recording	Control	KS-BMAL1 KO
Systolic blood pressure, mmHg
Male	127.1 ± 0.7 (4)	119.0 ± 2.3 (5)*†
Female	120.3 ± 1.6 (5)‡	118.5 ± 1.5 (7)†‡
Mean arterial pressure, mmHg
Male	110.2 ± 0.2 (4)	103.5 ± 2.2 (5)*†
Female	107.0 ± 1.0 (5)	104.1 ± 1.3 (7)†
Diastolic blood pressure, mmHg
Male	91.5 ± 0.8 (4)	86.3 ± 2.0 (5)†
Female	91.9 ± 1.3 (5)	87.8 ± 1.6 (7)†
Heart rate, beats/min
Male	585 ± 3 (4)	568 ± 9 (5)
Female	627 ± 12 (5)‡	614 ± 3 (7)‡
Pulse pressure, mmHg
Male	35.5 ± 1.4 (4)	32.7 ± 1.0 (5)
Female	28.3 ± 2.1 (5)‡	30.7 ± 1.6 (7)‡
Activity
Male	10.6 ± 0.7 (4)	10.2 ± 1.6 (5)
Female	10.4 ± 1.7 (5)	10.1 ± 0.5 (7)

Values are expressed as means ± SE with numbers of animals per group shown in parentheses. KS-BMAL1 KO mice, kidney-specific brain and muscle ARNT-like 1 knockout mice. Two-way ANOVA with Tukey multiple-comparisons test was used for statistical analysis.

^*Significantly differenct vs. control mice of the same sex (Tukey);

^†significantly different vs. control mice;

^‡significantly different vs. male mice.