Table 5.

Cosinor analysis of systolic blood pressure, mean arterial pressure, and diastolic blood pressure measured via telemetry from male and female mice under basal conditions

Cosinor Analysis	Control Mice	KS-BMAL1 KO Mice
Systolic blood pressure
Mesor§
Male	127 ± 0.7 (4)	119 ± 2 (5)*†
Female	120 ± 2 (5)‡	119 ± 1 (7)†‡
Amplitude
Male	12 ± 0.5 (4)	11 ± 0.7 (5)
Female	12 ± 0.7 (5)	13 ± 0.8 (7)
Period
Male	24 ± 0.02 (4)	24 ± 0.2 (5)
Female	24 ± 0.1 (5)	24 ± 0.1 (7)
Mean arterial pressure
Mesor
Male	110 ± 0.2 (4)	102 ± 2 (5)*†
Female	107 ± 1 (5)	103 ± 1 (7)†
Amplitude
Male	11 ± 1 (4)	10 ± 1 (5)
Female	11 ± 0.6 (5)	12 ± 0.7 (7)
Period
Male	24 ± 0.1 (4)	24 ± 0.2 (5)
Female	24 ± 0.1 (5)	24 ± 0.2 (7)
Diastolic blood pressure
Mesor
Male	91 ± 1 (4)	86 ± 2 (5)†
Female	92 ± 1 (5)	88 ± 2 (7)†
Amplitude§
Male	11 ± 1 (4)	9 ± 1 (5)
Female	10 ± 0.5 (5)	12 ± 0.8 (7)
Period
Male	24 ± 0.2 (4)	24 ± 0.2 (5)
Female	24 ± 0.1 (5)	24 ± 0.2 (7)

Values are expressed as means ± SE with numbers of animals per group shown in parentheses. The period, mesor, and amplitude were calculated for each parameter. KS-BMAL1 KO mice, kidney-specific brain and muscle ARNT-like 1 knockout mice. Two-way ANOVA with Tukey multiple-comparisons test was used for statistical analysis.

^*Significantly different vs. control mice of the same sex (Tukey);

^†significantly different vs. control mice;

^‡significantly different vs. male mice;

^§statistical difference in interaction.