TABLE 2.
Skeletal muscle genes upregulated with RT in Parkinson’s disease.
| Gene name | Description | Fold-change | FDR |
| Skeletal muscle development and remodeling | |||
| IGFN1 | Immunoglobulin-like and fibronectin type III domain containing 1 | 5.97 | 0.01 |
| COL1A1 | Collagen type I alpha 1 chain | 3.15 | 0.02 |
| COL3A1 | Collagen type III alpha 1 chain | 2.85 | 0.02 |
| COL4A1 | Collagen type IV alpha 1 chain | 2.75 | 0.02 |
| PANX1 | Pannexin 1 | 2.54 | 0.02 |
| CAPN6 | Calpain 6 | 2.49 | 0.02 |
| PXDN | Peroxidasin | 2.13 | 0.01 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | 2.05 | 0.05 |
| GJA1 | Gap junction protein alpha 1 | 2.01 | 0.02 |
| Nervous system development | |||
| PCDH17 | Protocadherin 17 | 3.51 | 0.05 |
| HTR7 | 5-hydroxytryptamine receptor 7 | 3.18 | 0.03 |
| ST8SIA2 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 | 3.13 | 0.03 |
| ADCYAP1R1 | ADCYAP receptor type I | 2.32 | 0.02 |
| FOXS1 | forkhead box S1 | 2.19 | 0.04 |
| HECW2 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 | 2.19 | 0.02 |
| NRP2 | Neuropilin 2 | 2.12 | 0.03 |
| Inflammation and immunity | |||
| CXCL9 | C-X-C motif chemokine ligand 9 | 3.47 | 0.03 |
| FCN3 | Ficolin 3 | 3.07 | 0.04 |
| MXRA5 | Matrix remodeling associated 5 | 2.91 | 0.03 |
| COL4A2 | Collagen type IV alpha 2 chain | 2.43 | 0.02 |
| NOS2 | Nitric oxide synthase 2 | 2.29 | 0.05 |
| FSCN1 | Fascin actin-bundling protein 1 | 2.20 | 0.02 |
| KCNC4 | Potassium voltage-gated channel subfamily C member 4 | 2.16 | 0.04 |
| LYZ | Lysozyme | 2.10 | 0.04 |
| Skeletal muscle metabolism | |||
| GAL3ST3 | Galactose-3-O-sulfotransferase 3 | 3.17 | 0.04 |
| NR5A2 | Nuclear receptor subfamily 5 group A member 2 | 2.91 | 0.04 |
| EXOC3L1 | Exocyst complex component 3 like 1 | 2.90 | 0.02 |
| MTFP1 | Mitochondrial fission process 1 | 2.28 | 0.02 |
| SLC7A1 | Solute carrier family 7 member 1 | 2.16 | 0.03 |
| RNF152 | Ring finger protein 152 | 2.04 | 0.02 |
| PD pathology | |||
| SIPA1L2 | Signal induced proliferation associated 1 like 2 | 4.61 | 0.01 |
| LOXHD1 | Lipoxygenase homology domains 1 | 4.41 | 0.03 |
| SCT | Secretin | 3.47 | 0.02 |
| VIPR1 | Vasoactive intestinal peptide receptor 1 | 2.62 | 0.02 |
| Lesser known function | |||
| HGC6.3 | Uncharacterized LOC100128124 | 3.28 | 0.03 |
| AC087289.5 | Novel transcript, antisense to TRIM47 | 3.14 | 0.03 |
| ITPRIPL1 | ITPRIP like 1 | 2.20 | 0.05 |
| DSTNP2 | Destrin, actin depolymerizing factor pseudogene 2 | 2.19 | 0.04 |
| PITPNM1 | Phosphatidylinositol transfer protein membrane associated 1 | 2.16 | 0.03 |
| AC015878.1 | Novel transcript, antisense to GREB1L | 2.13 | 0.03 |
| PCAT19 | Prostate cancer associated transcript 19 | 2.01 | 0.04 |
| C2CD4C | C2 calcium dependent domain containing 4C | 2.00 | 0.04 |
Fold-change in gene expression post-RT from pre-RT; FDR, false discovery rate.