TABLE 3.
Skeletal muscle genes downregulated with RT in Parkinson’s disease.
| Gene name | Description | Fold-change | FDR |
| Regulation of muscle growth and development | |||
| GREM2 | Gremlin 2, DAN family BMP antagonist | 0.15 | 0.04 |
| NPTX1 | Neuronal pentraxin 1 | 0.27 | 0.03 |
| MSTN | Myostatin | 0.33 | 0.02 |
| ACTN3 | Actinin alpha 3 (gene/pseudogene) | 0.36 | 0.02 |
| IL32 | Interleukin 32 | 0.43 | 0.02 |
| LOXL4 | Lysyl oxidase like 4 | 0.44 | 0.02 |
| RRAD | RRAD, Ras related glycolysis inhibitor and calcium channel regulator | 0.46 | 0.02 |
| TSPAN8 | Tetraspanin 8 | 0.48 | 0.03 |
| Autophagy and apoptosis | |||
| NME9 | NME/NM23 family member 9 | 0.35 | 0.02 |
| ARG2 | Arginase 2 | 0.35 | 0.04 |
| GGT7 | Gamma-glutamyltransferase 7 | 0.43 | 0.02 |
| SH3RF2 | SH3 domain containing ring finger 2 | 0.46 | 0.03 |
| Metabolism | |||
| GDA | Guanine deaminase | 0.25 | 0.04 |
| MYH1 | Myosin heavy chain 1 | 0.26 | 0.04 |
| CALML6 | Calmodulin like 6 | 0.27 | 0.01 |
| TRARG1 | Trafficking regulator of GLUT4 (SLC2A4) 1 | 0.33 | 0.05 |
| CACNA1E | Calcium voltage-gated channel subunit alpha1 E | 0.38 | 0.05 |
| PRKAG3 | Protein kinase AMP-activated non-catalytic subunit gamma 3 | 0.44 | 0.01 |
| SLC38A4 | Solute carrier family 38 member 4 | 0.44 | 0.02 |
| MYLK2 | Myosin light chain kinase 2 | 0.48 | 0.01 |
| GOLGA7B | Golgin A7 family member B | 0.48 | 0.02 |
| PARP15 | Poly(ADP-ribose) polymerase family member 15 | 0.49 | 0.04 |
| TTC39B | Tetratricopeptide repeat domain 39B | 0.50 | 0.03 |
| Lesser known function | |||
| UNQ6494 | Novel transcript | 0.25 | 0.03 |
| CFAP61 | Cilia and flagella associated protein 61 | 0.38 | 0.02 |
| LRRC3B | Leucine rich repeat containing 3B | 0.39 | 0.04 |
| FAM184B | Family with sequence similarity 184 member B | 0.39 | 0.02 |
| AC113133.1 | Novel transcript, antisense to ANK1 | 0.48 | 0.02 |
| ANKRD33B | Ankyrin repeat domain 33B | 0.50 | 0.02 |
Fold-change in gene expression post-RT from pre-RT; FDR, false discovery rate.