. 2020 Jun 24;267(11):3329–3336. doi: 10.1007/s00415-020-10004-4

Table 4.

Associations between continuous and categorical UPSIT scores and imaging outcomes in 389 cognitively normal individuals at age 69–71

	Continuous analyses			Categorical analyses
	UPSIT score			Hyposmia			Anosmia
	β	95% CI	p	β	95% CI	p	β	95% CI	p
Associations by linear regression (β coefficient)
Hippocampal volume (mL)^b,c	− 0.002	− 0.004, 0.011	0.805	− 0.075	− 0.200, 0.050	0.239	− 0.162	− 0.540, 0.217	0.401
Entorhinal cortex thickness (mm)^a,c	0.001	− 0.004, 0.006	0.671	0.010	− 0.039, 0.059	0.693	− 0.041	− 0.191, 0.108	0.587
Cortical thickness (mm)^a	0.001	− 0.001, 0.003	0.156	− 0.003	− 0.022, 0.017	0.771	0.001	− 0.058, 0.059	0.986
Global cognitive score (modified PACC)^a	− 0.003	− 0.017, 0.011	0.657	0.001	− 0.141, 0.140	0.992	0.252	− 0.172, 0.677	0.244
Associations by generalised linear model (exponentiated β coefficient)
White matter hyperintensity volume (mL)^b,d	0.992^e	0.967, 1.016	0.609	1.153^e	0.906, 1.468	0.247	1.280^e	0.624, 2.628	0.501

^aAdjusted for age and sex

^bAdjusted for age, sex and total intracranial volume

^cExpressed as the mean of right and left

^dn = 377 for this outcome

^eExpressed as exponentiated β coefficient; value represents the ratio change in WMHV per 1 point increase in UPSIT score, or between groups