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Effects of LRRK2 and α-synuclein on the autophagy-lysosomal pathway. This is an example of how LRRK2 and α-synuclein can have convergent mechanisms with both affecting the autophagy-lysosomal system but each acting on different targets within the system. Mutant or aggregated α-synuclein can block CMA and autophagosome formation, while mutant LRRK2 can also block CMA, disrupt mitophagy or delay autophagosome trafficking.
