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. 2020 Aug 20;182(4):828–842.e16. doi: 10.1016/j.cell.2020.06.025

Figure 2.

Figure 2

Plasma Fabs Bind to SARS-CoV-2 S Protein

(A) Schematic of polyclonal IgG and Fab purification from human plasma for nsEMPEM protocol.

(B and C) SEC profile of Fabs (B) and SDS-PAGE of purified IgGs and Fabs (C) from COV21, COV57, and COV107 plasma samples.

(D) SEC demonstration that plasma-derived Fabs from COV21 and COV57 shift the SARS-CoV-2 S protein trimer to a higher apparent molecular weight. No shift was observed when Fabs from COV107 were analyzed by SEC with S protein (data not shown). Fractions pooled and concentrated for nsEMPEM are boxed.

See also Figure S1.