Table 5.
In silico analysis of nonsynonymous SNPs of the PRNP gene in dogs.
| Polymorphisms | PolyPhen-2 | PROVEAN | PANTHER | ||||
|---|---|---|---|---|---|---|---|
| Score | Prediction | Score | Prediction | Score | Prediction | ||
| c.190_213del | p.64_71del HGGGWGQP | * NA | −13.135 | Deleterious | * NA | ||
| c.301A>G | Ser101Gly | 0.000 | Benign | −0.260 | Neutral | 85 | Probably benign |
| c.489C>G | Asp163Glu | 0.001 | Benign | −0.194 | Neutral | 85 | Probably benign |
| c.545A>G | Asp182Glu | 0.999 | Probably damaging | −1.452 | Neutral | 361 | Possibly damaging |
| c.546C>A | Asp182Gly | 1 | Probably damaging | −1.909 | Neutral | 361 | Possibly damaging |
* NA, Not available.