Figure 2.

Expression of leptin-targeted gene mRNA reduces survival of ER-negative breast cancer patients (BCER−). Survival curves of patients (n = 801) with low and high expression of (A) CDK8, (B) NANOG, and (C) RBP-Jk. Kaplan–Meier survival plots were calculated using data from the Cancer Genome Atlas (TCGA) [18,19,20,21]. Graphs depict relapse-free survival. Patients surviving beyond the timeline threshold (20 years and 10 months) were censored instead of excluded. Hazard ratio (HR) range and p-values (logrank P) were obtained for the BCER− patients using Kmplot.com software [18].