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A schematic representation of the effect of H3K4me3 trimethylation on DNMT3A enzyme activity. In the presence of H3K4me3 PTM, the DNMT3A enzyme is in an autoinhibitory form. In the case of the non-methylated H3K4me0, the enzyme interacts with the DNA in an active form where the arrangements of its ADD and CD domains is different from that in the autoinhibitory form.
