Table 4.
Biochemical evaluation of the NBC photodynamic effects in lung CSCs 24 h post-irradiation. A statistically significant increase in cytotoxicity and decrease in proliferation and viability was seen post-irradiation, using AlPcS4Cl-AuNP-PEG-COOH and AlPcS4Cl-AuNP-PEG-CD133 (p < 0.001(***)).
| Biochemical Assay | |||
|---|---|---|---|
| Experimental Group | Cytotoxicity (%) |
Proliferation (%) |
Viability (%) |
| Control | 15.3 ± 9.06 | 86.54 ± 6.5 | 76 ± 1.73 |
| AuNP-PEG-COOH | 32.47 ± 9.69 | 84.77 ± 6.59 | 80.66 ± 4.66 |
| AuNP-PEG-COOH + irradiation | 38.26 ± 16.09 | 93.51 ± 2.27 | 81.66 ± 5.23 |
| AlPcS4Cl- AuNP-PEG-COOH | 35.96 ± 6.66 | 84.35 ± 10.6 | 86.66 ± 3.75 |
| AlPcS4Cl- AuNP-PEG-COOH + irradiation | (***) 97.07 ± 2.74 |
(***) 7.72 ± 8.36 |
(***) 30.33 ± 2.33 |
| AlPcS4Cl- AuNP-PEG-CD133 | 27.73 ± 6.38 | 100 ± 6.74 | 72.33 ± 2.4 |
| AlPcS4Cl- AuNP-PEG-CD133 + irradiation | (***) 93.4 ± 6.39 |
(***) 10.59 ± 13.9 |
(***) 15.33 ± 1.76 |