Table 2.
List of potential endocrine targets identified as relevant for ED-induced DNT using in silico prediction.
| Target Name | Chemicals | Type of Interaction |
|---|---|---|
| Estrogen receptor alpha and beta | BPA | Agonistic |
| Estradiol 17-beta-dehydrogenase 1 | Endosulfan | Binding |
| Androgen receptor | BPA, endosulfan, 4,4′-DDE, PFHxS | Antagonistic |
| Thyroid hormone receptor beta | BPA, cypermethrin, endosulfan, PFHxS, permethrin | Agonistic |
| Glucocorticoid receptor | BPA, MEHP | Agonistic |
| Retinoic acid receptor alpha, beta, gamma | 3-PBA, MEP, MIDP, MINP | Agonistic/not predicted |
| Progesterone receptor | BPA, MEHP | Not predicted |
| Peroxisome proliferator-activated receptor alpha, gamma, delta | Permethrin | Agonistic |
| Vitamin D3 receptor | Permethrin | Agonistic |
| Oxysterols receptor LXR-alpha | PFHxS, PFOA, PFOS | Agonistic |
| Prostaglandin E2 receptor EP1, EP2, EP3, EP4 subtype | MBzP |
BPA: bisphenol A, 4,4′-DDE: dichlordiphenyldichlorethylen, MBzP: monobenzyl phthalate, MEHP: mono (2-ethylhexyl) phthalate, MEP: mono-ethylphthalic acid ester, MIDP: mono-isodecylphthalic acid ester, MINP: monoisononyl phthalate, PFHxS: perfluorohexanesulfonic acid, PFOA: perfluorooctanoic acid, and PFOS: perfluorooctanesulfonic acid.