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. 2020 Jun 8;21(11):4097. doi: 10.3390/ijms21114097

Figure 1.

Figure 1

Lipopolysaccharide induces sickness behavior in pregnant female rats. LPS (100 µg/kg body weight) was injected intraperitoneally to pregnant rats at gestation day 9.5. The body weight, food intake, water intake and body temperature were recorded. (a) Study design. GD—gestation day, PND—postanal day ISO—maternal isolation test, BD—bedding preference test, OF—open field test, TCK—tickling test, 3-CH—three chamber social test. (b) The change in body weight during 24 h post-injection (n = 4). (c) Food intake during 24 h post-injection (n = 4). (d) Water intake during 24 h post-injection (n = 4). (e) The change in rectal body temperature during 6 h post-injection (n = 4). * p < 0.05, compared to control group using Student’s t-test.