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. 2020 Jun 8;21(11):4097. doi: 10.3390/ijms21114097

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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MIA does not affect exploration of open field (OF) in adolescent rats. Effects of MIA on general locomotor activity and anxiety were measured in open field test in PND 40 male rats. The locomotion behavior was analyzed by measuring total traveled distance (a) and velocity (b) of MIA animals and saline-treated controls. The anxiety-related behavior was examined by measurement of central (c) and peripheral (d) zone exploration of MIA animals and controls. n = 28 and 34 in control group and in MIA group, respectively. Data represent medians with interquartile range, minimum, and maximum.