Figure 5.

MIA induces neuro-inflammatory responses in blood and brain of offspring rats. Offspring male rats at PND 52–54 were sacrificed and blood and brain tissues were collected. (a–d) Effects of prenatal LPS exposure on mRNA for pro-inflammatory proteins in cerebral cortex of offspring rats. The mRNA levels were measured by real time-PCR, and normalized to Actb (β-actin). (e–h) Effects of prenatal LPS exposure on pro-inflammatory cytokines in blood, as determined by using the Bio-Plex Pro Rat Cytokine 23-Plex Assay. Data represent the mean value ± S.E.M. (a–n = 4, b–n = 4, c–n = 4–5, d–n = 9–10, e–n = 7–14, f–n = 6–10, g–n = 6–10, h–n = 6–12). * p < 0.05, compared to control group using Student‘s t-test.