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. 2020 Jun 24;34(4):423–433. doi: 10.1007/s40259-020-00429-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 1 — Representations of a single designed ankyrin repeat domain and a multidomain DARPin^® drug candidate. a Ribbon representation of an ankyrin repeat domain (PDB ID: 1MJ0) consisting of five repeats, with randomized interaction colored in orange and a transparent surface superimposed. b Molecular model of MP0250, a DARPin^® drug candidate consisting of four DARPin^® domains (molecular weight approximately 62 kDa). The scaffold is dark blue, and the potential target interaction residues of the individual domains are orange (human serum albumin [HSA]), cyan (hepatocyte growth factor [HGF]), and red (vascular endothelial growth factor [VEGF])