Table 1.

Comparison of monoclonal antibodies and a DARPin^® candidate

	Classical IgG	MP0250 DARPin® drug candidate
Molecular weight (kDa)	150	62
Number of polypeptide chains	4	1
Disulfide bonds	Yes	No
Effector function	Yes	No
Engineered target specificities	1	3
Binding mode	Flexible loops	Rigid secondary structure elements
Half-life extension	Fc	Serum albumin binding
Production in	Mammalian cells	Escherichia coli

IgG immunoglobulin G