Figure 2.

Schematic of the titin-N2A signaling complex. MARP1 and 2 bind competitively to N2A titin’s unique sequence (UNA), located between Ig80 and Ig81. CAPN3 binding is localized to both Ig80/UN2A and Ig82/Ig83. Myopalladin (MYPN) associates with the N-terminal domains of MARPs. Adapted from Miller et al. [41] and Hayashi et al. [43].