Figure 9.

Quantitative analysis of phosphatidylserine externalization and membrane disruption in MCF-7 and HCT116 cells after 120 h of treatment with C-1305 and C-1311 at IC₉₀. (A) Three types of PI-positive stained MCF-7 cells after 120 h of C-1305 and C-1311 treatment; (B) Populations of cells from individual quadrants: annexin V positive or annexin V and PI positive or PI positive, obtained from annexin V/PI test conducted for three types of MCF-7 and HCT116 cells exposed to C-1305 and C-1311 at IC₉₀. Significant differences in cell percentages between control, stably transfected with EV cells and UGT1A10- or CYP3A4-transfected are indicated as follows: * p ≤ 0.05; ** p ≤ 0.001.