Figure 2.

Exposure level influences gene expression profiles. A, Analysis of tuberculin skin test (TST) converters vs nonconverters with low exposure. B, Analysis of TST converters vs nonconverters with high exposure. Exposure was defined based on smear grade of the index case and sleeping proximity of the contact to the index case. Only the high-exposure group showed the B-cell signature seen when all samples were analyzed (rectangles). Depth of color indicates significance level, and size indicates effect. Abbreviations: ATF, activating transcription factor; C-MYC, c-Master Regulator of Cell Cycle Entry and Proliferative Metabolism; TLR, Toll-like receptor.