Table 2.
Differentially Expressed Genes in the Tuberculin Skin Test Group With a False Discovery Rate ≤0.01
| Gene | Log-fold Change | P Value | False Discovery Rate | Description |
|---|---|---|---|---|
| TMEM56 | 2.29 | 1.25E-08 | 1.95E-04 | Transmembrane protein 56; protein coding |
| RP11-364L4.1 | 2.83 | 4.52E-08 | 3.54E-04 | Pseudogene |
| LCN2 | 2.42 | 1.81E-07 | 9.43E-04 | Lipocalin 2; iron sequestering; innate immunity |
| CLIC2 | 1.22 | 3.50E-07 | 1.11E-03 | Chloride intracellular channel; regulates cell processes |
| WASHC3 | 0.60 | 3.54E-07 | 1.11E-03 | Endocytosis |
| AC010642.1 | −1.50 | 8.25E-07 | 2.15E-03 | Zinc finger protein pseudogene |
| CCDC153 | 1.43 | 1.25E-06 | 2.79E-03 | Coiled-coil domain-containing protein 153 |
| HNMT | 1.28 | 1.60E-06 | 3.01E-03 | Inactivates histamine by N-methylation |
| FAM114A1 | 1.59 | 1.73E-06 | 3.01E-03 | Protein coding gene; neuronal cell development |
| MED20 | 0.92 | 2.03E-06 | 3.18E-03 | Transcriptional coactivator complex |
| RAB10 | 0.80 | 3.17E-06 | 4.36E-03 | Regulates intracellular vesicle trafficking |
| TCF4 | −0.89 | 3.52E-06 | 4.36E-03 | Transcription factor 4; extracellular signal regulated kinase signaling |
| CXCL9 | 2.39 | 3.62E-06 | 4.36E-03 | T-cell trafficking; antimicrobial |
| SLC14A1 | 1.80 | 3.95E-06 | 4.42E-03 | Mediates urea transport in erythrocytes |
| ATG3 | 0.67 | 4.56E-06 | 4.76E-03 | Regulation of autophagy during cell death |
| ANAPC13 | 0.79 | 4.93E-06 | 4.82E-03 | Class I major histocompatibility complex antigen processing and presentation |
| TRIQK | 0.75 | 5.89E-06 | 5.20E-03 | Cell growth and maintenance of cell morphology |
| GLRX | 1.10 | 5.98E-06 | 5.20E-03 | Member of glutaredoxin family; antioxidant defense |
| NCOA4 | 0.98 | 8.41E-06 | 6.92E-03 | Androgen receptor binding |
| BNIP3L | 1.26 | 9.52E-06 | 7.45E-03 | Pro-apoptotic subfamily within B-cell lymphoma-2 family of proteins |
| LINC00662 | 1.23 | 1.05E-05 | 7.68E-03 | Noncoding RNA |
| DPCD | 0.95 | 1.08E-05 | 7.68E-03 | Possible role in the formation/function of ciliated cells |
| ARV1 | 1.09 | 1.15E-05 | 7.84E-03 | Endoplasmic reticulum cholesterol and bile acid homeostasis |
| ARL6IP5 | 0.73 | 1.35E-05 | 8.27E-03 | Regulates intracellular concentrations of taurine and glutamate; expression affected by vitamin A |
| FBXO9 | 0.78 | 1.37E-05 | 8.27E-03 | F-box protein family; phosphorylation-dependent ubiquitination |
| DENND5B | −1.24 | 1.37E-05 | 8.27E-03 | Promotes the exchange of guanosine diphosphate to guanosine triphosphate |
| TBC1D27 | −1.14 | 1.47E-05 | 8.37E-03 | Pseudogene |
| OLFM4 | 3.14 | 1.50E-05 | 8.37E-03 | Olfactomedin 4; antiapoptotic factor that promotes tumor growth |
| TMEM55A | 1.02 | 1.57E-05 | 8.49E-03 | Superpathway of inositol phosphate compounds |
| EVPL | 1.42 | 1.81E-05 | 9.44E-03 | Member of the plakin family of proteins; component of desmosomes and epidermal cornified envelope |
| IGFBP7 | 0.97 | 1.98E-05 | 9.79E-03 | Member of the insulin-like growth factor–binding protein family |
| DCAF6 | 0.72 | 2.03E-05 | 9.79E-03 | Ligand-dependent coactivator of nuclear receptors |
| FAM26F | 1.32 | 2.07E-05 | 9.79E-03 | Calcium homeostasis modulator family member 6 |