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. 2020 Apr 22;7(12):2000192. doi: 10.1002/advs.202000192

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© 2020 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Liquid metal nanoparticles for drug delivery. a) Nanomedicine based on liquid metal nanoparticles can enter tumor cells by endocytosis and fuse under low pH to accelerate the release of drugs from the surface of the particles. MUA‐CD is a thiolated cyclodextrin molecule that binds to themetal particles and holds doxorubicin (Dox), a cancer drug. m‐HA is a thiolated hydraluronic acid that binds to the metal particle surface and serves as a targeting moiety for the CD44 receptor, which is over‐expressed on tumors. Reproduced with permission.^[ ⁴⁷ ^] Copyright 2015, Nature Publishing Group. b) Coated with graphene quantum dots, liquid metal nanomedicine can transform from a spherical shape to a solid rod shape in tumor cells when exposed to near‐IR light due to the oxidation of the metal. Reproduced with permission.^[ ⁸⁸ ^] Copyright 2017, American Chemical Society.