TABLE 1.

Final parameter estimates of the kinetic PBGD_L model

Parameter	Estimate (RSE)
θ SLP (kg·pmol−1)	250 (35%)
K LP (days−1)	0.00892 (29%)
K PL (days−1)	0.00375 (43%)
σ (residual error, %)	28.8 (6%)

Formulation specific	LNP‐A		LNP‐B and LNP‐C
K REL (days−1)	0.323 (20%)		0.129 (15%)

Animal species specific	AIP mouse	WT—rat	WT—rabbit	WT—cyno
PBGDL(0) (pmol·mg protein−1·hr−1)	3 FIX	12.4 FIX	9.37 FIX	5.54 FIX

mRNA sequence specific	SEQ‐1 and SEQ‐2	SEQ‐3	SEQ‐4	SEQ‐5	SEQ‐6
K DEG (days−1)	0.0056 (24%)	0.0016 (22%)	0.00889 (30%)	0.00767 (37%)	0.000256 (21%) a

RSE, relative standard error.

^aParameter estimated using data from WT animals.