Table 3.
Univariable and multivariable Cox regression analyses for mortality
| Parameter | Univariable analysis | Multivariable analysis | ||||
| HR | 95% CI* | P value | HR | 95% CI* | P value | |
| Age | 1.01 | 1.00 to 1.03 | 0.252 | – | ||
| Male gender | 0.70 | 0.42 to 1.20 | 0.186 | – | ||
| Hypertension | 1.13 | 0.63 to 2.00 | 0.684 | – | ||
| Atrial fibrillation | 4.36 | 2.56 to 7.41 | <0.0001 | 2.17 | 1.20 to 3.93 | 0.011 |
| Hypercholesterolemia | 0.88 | 0.50 to 1.56 | 0.670 | – | ||
| Coronary heart disease | 1.97 | 1.06 to 3.65 | 0.031 | 1.44 | 0.76 to 2.71 | 0.262 |
| Previous TIA or stroke | 1.25 | 0.65 to 2.42 | 0.499 | – | ||
| Active smoking | 1.48 | 0.88 to 2.49 | 0.135 | – | ||
| BMI | 0.96 | 0.88 to 1.04 | 0.301 | – | ||
| Systolic blood pressure | 0.99 | 0.98 to 1.00 | 0.135 | – | ||
| Diastolic blood pressure | 1.00 | 0.98 to 1.01 | 0.620 | – | ||
| Reperfusion therapy | 1.27 | 0.46 to 3.75 | 0.659 | – | ||
| NIHSS score at admission | 1.20 | 1.14 to 1.20 | <0.0001 | 1.11 | 1.08 to 1.15 | <0.0001 |
| Large-vessel occlusive disease† | 0.88 | 0.31 to 2.46 | 0.802 | – | ||
| Small-vessel occlusive disease† | 0.02 | 0.00 to 0.13 | <0.0001 | 0.07 | 0.12 to 0.38 | 0.002 |
| Cardioembolic† | 1.05 | 0.35 to 3.19 | 0.933 | – | ||
| HbA1c (%) | 1.46 | 1.30 to 1.65 | <0.0001 | 1.32 | 1.15 to 1.51 | <0.0001 |
| FBG | 1.17 | 1.12 to 1.22 | <0.0001 | 1.10 | 1.03 to 1.15 | 0.004 |
*Note that the hazard ratio corresponds to a unit increase in the explanatory variable.
†Other and unknown ischaemic stroke subtype as the reference.
BMI, body mass index; FBG, fasting blood glucose; HbA1c, glycated haemoglobin; NIHSS, National Institutes of Health Stroke Scale; TIA, transient ischaemic attack.