Figure 5.

Therapeutic effect of MTIT in U87‐bearing mice. A) Schematic illustration the process of in vivo treatment. RGD‐IONs were intratumorally injected with iron 5 mg kg⁻¹ per time for three times at day 0, 2, and 4. The treatments were performed for seven times, at day 1, 3, 5, 7, 9, 11, and 13, respectively. The parameters of RMF 40 mT, 15 Hz, and 30 min. The parameters of AMF were 375 kHz, 12 kA m⁻¹ and 6 min. B) Body weight recorded daily for 3 weeks. C) Mice pictures at day 5 and day 21. D,E) Tumor pictures and tumor weight obtained after dissection for four groups. Statistical analysis was performed using t‐test with *** indicating p < 0.001, ** indicating p < 0.01 and * indicating p < 0.05. Error bars represent standard deviation. F) H&E staining and Prussian blue staining of tumor tissues dissected from the mice at day 21. Scale bar: 200 µm.