Scheme 1.

Magneto‐mechanical thermal induction therapy (MTIT) based on the assembly of nanocubes and alternating magnetic fields. The nanocubes were modified to obtain RGD functionalized nanocubes (RGD‐IONs) with cancer and neovasculature targeting ability. After internalized into lysosomes, MTIT treatment was carried out. Under 15 Hz rotating magnetic field, MF generated from assembled nanocubes rotation impaired the lysosomal membrane permeability and elevated the intracellular ROS, making cells sensitive to the subsequent heating. MH under 375 kHz alternating magnetic field further physically destroyed the lysosomes structure, induced the depolarization of mitochondria and changed the biological ROS level, leading to cell death. There was a synergistic effect between MF and MH, achieving highly efficient therapeutic effect both in vitro and in vivo.