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. 2020 Jun 23;8(1):e000842. doi: 10.1136/jitc-2020-000842

Figure 2.

Figure 2

Baseline serum IL-6 levels are associated with overall survival (OS). Kaplan-Meier survival curves were determined for three independent clinical trials for patients stratified according to the median baseline serum levels or the lower limit of quantification (LLOQ). Patients below the median or LLOQ are represented by blue lines and those above by red lines. (A) Patients in Checkmate-064 received sequential nivolumab then ipilimumab (cohort A) or sequential ipilimumab then nivolumab (cohort B); median IL-6, 13.3 pg/mL. (B) Patients in Checkmate-066 were treated with nivolumab or dacarbazine; LLOQ IL-6, 6 pg/mL. (C) Patients in Checkmate-067 received nivolumab or ipilimumab alone, or concurrent nivolumab and ipilimumab; LLOQ IL-6, 11 pg/mL. HR adjusted for ECOG, BRAF, M stage, baseline LDH, and melanoma subtype. IL, interleukin; M, metastases; ECOG, Eastern Cooperative Oncology Group; LDH, Lactate Dehydrogenase.