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. 2020 May 27;21(11):3817. doi: 10.3390/ijms21113817

Figure 1.

Figure 1

Erythropoietin (EPO) induces dose-dependent trabecular bone loss. (a) Relationship between the hemoglobin level (grey) and the extent of reduction in BV/TV (black) at different doses of EPO. The values on the X axis represent a total weekly dose of EPO administered to 10-week-old female mice for two weeks. Values on the Y axis are mean ± SD; n = 3 for 6 and 12 IU, n = 7 and 8 for 24 and 540 IU, respectively. (b) Representative 3D reconstruction images of the distal femoral metaphysis of mice treated with diluent or EPO at the designated doses. * p < 0.05 relative to diluent control, † p < 0.05 relative to preceding dose, ‡ p = 0.05 relative to preceding dose.